高强度
流体衰减反转恢复
白质疏松症
医学
磁共振成像
脑脊液
队列
冲程(发动机)
血管周围间隙
病理
放射科
心脏病学
机械工程
工程类
作者
Junfang Zhang,Hwee Fang Lim,Francesca M Chappell,Úna Clancy,Stewart Wiseman,Maria del C. Valdés Hernández,Daniela Jaime García,Mark E. Bastin,Fergus Doubal,Will Hewins,Simon R. Cox,Susana Muñoz Maniega,Michael J. Thrippleton,Michael Stringer,Charlotte Jardine,Donna McIntyre,G. Robin Barclay,I. Hamilton,Lucy Kesseler,Madeleine Murphy,Carol Di Perri,Yun-Cheng Wu,Joanna M. Wardlaw
标识
DOI:10.1016/j.neurobiolaging.2021.06.013
摘要
Raised signal in cerebrospinal fluid (CSF) on fluid-attenuated inversion recovery (FLAIR) may indicate raised CSF protein or debris and is seen in inferior frontal sulci on routine MRI. To explore its clinical relevance, we assessed the association of inferior frontal sulcal hyperintensities (IFSH) on FLAIR with demographics, risk factors, and small vessel disease markers in three cohorts (healthy volunteers, n=44; mild stroke patients, n=105; older community-dwelling participants from Lothian birth cohort 1936, n=101). We collected detailed clinical data, scanned all subjects on the same 3T MRI scanner and 3-dimensional FLAIR sequence and developed a scale to rate IFSH. In adjusted analyses, the IFSH score increased with age (per 10-year increase; OR 1.69; 95% CI, 1.42-2.02), and perivascular spaces score in centrum semiovale in stroke patients (OR 1.73; 95% CI, 1.13-2.69). Since glymphatic CSF clearance declines with age and drains partially via the cribriform plate to the nasal lymphatics, IFSH on 3T MRI may be a non-invasive biomarker of altered CSF clearance and justifies further research in larger, more diverse samples.
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