PI3K/AKT/mTOR通路
蛋白激酶B
信号转导
葛兰素史克-3
疾病
神经保护
神经毒性
医学
激酶
神经退行性变
生物
癌症研究
药理学
生物信息学
神经科学
细胞生物学
内科学
毒性
作者
Hui-Zhi Long,Yan Cheng,Ziwei Zhou,Hongyu Luo,Dan-Dan Wen,Lichen Gao
标识
DOI:10.3389/fphar.2021.648636
摘要
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, the health problem and economic burden caused by the two diseases also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction and biological processes such as cell proliferation, apoptosis and metabolism. According to reports, it regulates neurotoxicity and mediates the survival of neurons through different substrates such as forkhead box protein Os (FoxOs), glycogen synthase kinase-3β (GSK-3β), and caspase-9. Accumulating evidences indicate that some natural products can play a neuroprotective role by activating PI3K/AKT pathway, providing an effective resource for the discovery of potential therapeutic drugs. This article reviews the relationship between AKT signaling pathway and AD and PD, and discusses the potential natural products based on the PI3K/AKT signaling pathway to treat two diseases in recent years, hoping to provide guidance and reference for this field. Further development of Chinese herbal medicine is needed to treat these two diseases.
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