光热治疗
药物输送
纳米材料
纳米医学
胶体金
荧光
光电子学
纳米载体
作者
M. Zhao,E. Leggett,Struan Bourke,Souzana Poursanidou,Sadie Carter-Searjeant,S. Po,M. P. Carmo,Lea Ann Dailey,Philip Manning,Sean G Ryan,Laura Urbano,Mark Green,Aliaksandra Rakovich
出处
期刊:ACS Nano
[American Chemical Society]
日期:2021-05-12
卷期号:15 (5): 8790-8802
被引量:2
标识
DOI:10.1021/acsnano.1c01257
摘要
Conjugated polymer nanoparticles (CPNs) based on a common solar cell material (PTB7) have been prepared, and their potential in theranostic applications based on bioimaging and photosensitizing capabilities has been evaluated. The main absorption and emission bands of the prepared CPNs both fell within the NIR-I (650-950 nm) transparency window, allowing facile and efficient implementation of our CPNs as bioimaging agents, as demonstrated in this work for A549 human lung cancer cell cultures. The prepared CPN samples were also shown to produce reactive oxygen species (ROS) upon photoexcitation in the near-infrared or ultraviolet spectral regions, both in aqueous solutions and in HaCaT keratinocyte cell cultures. Importantly, we show that the photosensitizing ability of our CPNs was largely determined by the nature of the stabilizing shell: coating the CPNs with a Pluronic F-127 copolymer led to an improvement of photoinitiated ROS production, while using poly[styrene-co-maleic anhydride] instead completely quenched said process. This work therefore demonstrates that the photosensitizing capability of CPNs can be modulated via an appropriate selection of stabilizing material and highlights the significance of this parameter for the on-demand design of theranostic probes based on CPNs.
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