间质液
化学
生物传感器
离子导入
安培法
生物医学工程
皮肤刺激
可穿戴计算机
连续血糖监测
糖尿病
电极
嵌入式系统
计算机科学
内科学
电化学
医学
生物化学
1型糖尿病
皮肤病科
内分泌学
物理化学
放射科
作者
Ernesto De la Paz,Abbas Barfidokht,Samantha Rios,Christopher M. Brown,E. Chao,Joseph Wang
出处
期刊:Analytical Chemistry
[American Chemical Society]
日期:2021-09-03
卷期号:93 (37): 12767-12775
被引量:51
标识
DOI:10.1021/acs.analchem.1c02887
摘要
An effective, noninvasive glucose monitoring technology could be a pivotal factor for addressing the major unmet needs for managing diabetes mellitus (DM). Here, we describe a skin-worn, disposable, wireless electrochemical biosensor for extended noninvasive monitoring of glucose in the interstitial fluid (ISF). The wearable platform integrates three components: a screen-printed iontophoretic electrode system for ISF extraction by reverse iontophoresis (RI), a printed three-electrode amperometric glucose biosensor, and an electronic interface for control and wireless communication. Prolonged on-body glucose monitoring of up to 8 h, including clinical trials conducted in individuals with and without DM, demonstrated good correlation between glucose blood and ISF concentrations and the ability to monitor dynamically changing glucose levels upon food consumption, with no evidence of skin irritation or discomfort. Such successful extended operation addresses the challenges reported for the GlucoWatch platform by using a lower RI current density at shorter extraction times, along with a lower measurement frequency. Such a noninvasive skin-worn platform could address long-standing challenges with existing glucose monitoring platforms.
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