Macrophage Ubiquitin-Activating Enzyme 1 Promotes Sepsis-Associated Acute Kidney Injury by Relieving Nucleoporin 35–Mediated Suppression of Nuclear Factor-κB Signaling

AIMS: To determine the role of the ubiquitin-activating enzyme UBA1 in macrophage-mediated renal injury during sepsis-associated acute kidney injury (SA-AKI) and to elucidate the underlying molecular mechanism. METHODS AND RESULTS: . INNOVATION AND CONCLUSIONS: 00, 000-000.