The simulation of optical wavefront decomposition on Zernike polynomials based on the multi-channel diffractive optical element (DOE) was performed. This approach is an alternative to classical wavefront sensors and may be used to determine weighted values of aberrations in the analysed wavefront in real time thus, facilitating the aberrometry analysis of the human eye optical system. An investigation of multi-channel analysers was performed on test examples and the applicability of the techniques in solving particular applications are defined.