骨关节炎
类风湿性关节炎
医学
硫化氢
炎症
关节炎
线粒体
分解代谢
免疫学
生物信息学
病理
内科学
化学
生物
生物化学
新陈代谢
硫黄
替代医学
有机化学
作者
E.F. Burguera,Rosa Meijide-Faílde,Francisco J. Blanco
出处
期刊:Current Drug Targets
[Bentham Science]
日期:2017-10-09
卷期号:18 (14)
被引量:39
标识
DOI:10.2174/1389450117666160829112824
摘要
Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with important physiologic functions in the brain, vasculature and other organs. Recent studies have found H2S to be a mediator in inflammatory joint diseases. Objective: This review summarizes the recent literature in this area highlighting relevant developments. Conclusions: Several authors have found that H2S exhibited anti-inflammatory, anti-catabolic and/or anti-oxidant effects in rodent models of acute arthritis and in in vitro models using human synoviocytes and articular chondrocytes from RA and OA tissues. The earliest studies used fast-dissolving salts, such as NaSH, but GYY4137, which produces H2S more physiologically, shortly appeared. More recently still, new H2S-forming compounds that target mitochondria have been synthesized. These compounds open exciting opportunities for investigating the role of H2S in cell bioenergetics, typically altered in arthritides. Positive results have also been obtained when H2S is administered as a sulphurous water bath, an option meriting further study. These findings suggest that exogenous supplementation of H2S may provide a viable therapeutic option for these diseases, particularly in OA. Keywords: Inflammatory joint diseases, rheumatoid arthritis, osteoarthritis, hydrogen sulfide, mitochondria, sulphurous spring waters.
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