Bacteriophage lysins as antibacterials

We read the editorial entitled "Non-antibiotic treatments for bacterial diseases in an era of progressive antibiotic resistance" by Steven M. Opal published in Critical Care [1].We want to congratulate the author for this timely editorial and appreciate the efforts to highlight various non-antibiotic-based approaches being pursued for treating drug-resistant bacteria.We fully agree that there is a need to consider these approaches as serious alternatives to conventional antibiotics.In the editorial, six possible options have been listed as non-antibiotic inhibitors of bacterial growth.We agree that these are viable options which include devices and chemical or biological compounds for addressing the problem of bacterial drug-resistance.Although we understand that this is not an exhaustive list of possible options, we would like to suggest that bacteriophage "lysins", including both endolysins (which help the phage in releasing the intracellular virus particles by cleaving the peptidoglycan from inside) and ectolysins (which help the phage in injecting DNA into the bacterial cell by cleaving the peptidoglycan on the external surface) can also be considered as alternative options for treating drug-resistant bacteria.When added to a bacterial culture