骨水泥
抗菌剂
药物输送
抗生素
关节置换术
输送系统
医学
全髋关节置换术
膝关节置换术
抗生素耐药性
关节感染
全关节置换术
材料科学
纳米技术
关节置换术
生物医学工程
外科
微生物学
水泥
复合材料
假体周围
生物
作者
Yazan Al Thaher,Stefano Perni,Polina Prokopovich
标识
DOI:10.1016/j.cis.2017.04.017
摘要
Total joint replacement (TJR), such as hip and knee replacement, is a popular procedure worldwide. Prosthetic joint infections (PJI) after this procedure have been widely reported, where treatment of such infections is complex with high cost and prolonged hospital stay. In cemented arthroplasties, the use of antibiotic loaded bone cement (ALBC) is a standard practice for the prophylaxis and treatment of PJI. Recently, the development of bacterial resistance by pathogenic microorganisms against most commonly used antibiotics increased the interest in alternative approaches for antimicrobial delivery systems such as nanotechnology. This review summarizes the efforts made to improve the antimicrobial properties of PMMA bone cements using nanotechnology based antibiotic and non-antibiotic delivery systems to overcome drawbacks of ALBC in the prophylaxis and treatment of PJIs after hip and knee replacement.
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