Organic AIE Nanoradiosensitizer Potentiates X‐Ray Triggered Continuous Reactive Oxygen Species Generation for Potent Cancer Radioimmunotherapy

to continuously produce hydroxyl radicals. The double-promoting ROS generation of THN induced massive immunogenic cancer cell death and polarized M2 macrophages into the M1 phenotype for enhanced antitumor immunotherapy. Experiments revealed that THN-sensitized RT inhibited tumor recurrence and increased memory T-cell proportion for long-term antitumor immunity. The developed ORS has great clinical potential as both a radiosensitizer and a post-RT immunomodulatory agent.