IQGAP-1 Mediated Activation of the Kupffer Cells Contributes to the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease

In conclusion, our research findings indicate that IQGAP-1 regulates the KCs-HSCs axis through multiple pathways, participating in the progression and exacerbation of MASLD, thus providing novel therapeutic targets for the treatment of MASLD.