Mechanically‐Compliant Magnetoelectric Sutures for Wound Management

Abstract Sutures are the standard approach for wound closure and surgical incisions, but their clinical utility is constrained by inherent mechanical mismatch and the absence of multifunctional capabilities. While electrical stimulation has emerged as a promising nonpharmacological strategy for accelerated wound healing, achieving seamless integration of on‐demand, untethered electrical stimulation with suture systems persists as a critical challenge. Here, a magnetoelectric suture is developed by incorporating core‐shell magnetoelectric nanoparticles within a piezoelectric P(VDF‐TrFE) matrix. Upon external magnetic field exposure, magneto‐mechano‐electric cascade synergistically generated a programmable electrical output, thereby enabling spatiotemporally controlled electrical stimulation at the wound site. The ME suture is engineered with a polyzwitterionic hydrogel skin, imparting them with improved mechanical compliance, biocompatibility, and reduced foreign body response, and enabling friction‐minimized removal. In a rat incisional wound model, the ME suture with daily magnetic induction achieved significantly faster healing by reducing the recovery time from ten days to just five days. This work establishes a paradigm for intelligent suture systems, offering a theranostic platform that synergizes mechanoadaptive properties with electrically augmented tissue repair for next‐generation wound management.