脚手架
软骨细胞
细胞生物学
材料科学
间充质干细胞
生物医学工程
化学
再生(生物学)
软骨
解剖
生物
医学
作者
Cheng Ji Li,Jeong‐Hui Park,Geng Jin,Nandin Mandakhbayar,Dong-Hyeon Yeo,Jun Hee Lee,Jung Hwan Lee,Hye Sung Kim,Hae‐Won Kim
标识
DOI:10.1002/adhm.202400154
摘要
Abstract Articular cartilage defects are a global challenge, causing substantial disability. Repairing large defects is problematic, often exceeding cartilage's self‐healing capacity and damaging bone structures. To tackle this problem, we develop a scaffold‐mediated therapeutic ion delivery system. These scaffolds are constructed from poly(ε‐caprolactone) and strontium (Sr)‐doped bioactive nanoglasses (SrBGn), creating a unique hierarchical structure featuring macro‐pores from 3D printing, micro‐pores, and nano‐topologies due to SrBGn integration. The SrBGn‐embedded scaffolds (SrBGn‐μCh) release Sr, silicon (Si), and calcium (Ca) ions, which improve chondrocyte activation, adhesion, proliferation, and maturation‐related gene expression. This multiple ion delivery significantly affects metabolic activity and maturation of chondrocytes. Importantly, Sr ions may play a role in chondrocyte regulation through the Notch signaling pathway. Notably, the scaffold's structure and topological cues expedite the recruitment, adhesion, spreading, and proliferation of chondrocytes and bone marrow‐derived mesenchymal stem cells. Si and Ca ions accelerate osteogenic differentiation and blood vessel formation, while Sr ions enhance the polarization of M2 macrophages. Our findings show that SrBGn‐μCh scaffolds accelerate osteochondral defect repair by delivering multiple ions and providing structural/topological cues, ultimately supporting host cell functions and defect healing. This scaffold holds great promise for osteochondral repair applications. This article is protected by copyright. All rights reserved
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