PKM2 's Dual Role in Periodontitis: Regulating Inflammation and Bone Metabolism Imbalance

As a core hub connecting microbial dysbiosis, host metabolic reprogramming, and pathological outcomes, PKM2's dual functional properties offer a novel therapeutic target for periodontitis beyond conventional antimicrobial/anti-inflammatory strategies. Targeting PKM2 or its downstream metabolic-immune crosstalk may represent a breakthrough for halting disease progression.