铑
催化作用
氮原子
产量(工程)
复分解
化学
臭氧分解
氮气
分子内力
组合化学
立体化学
有机化学
材料科学
群(周期表)
聚合
聚合物
冶金
作者
Azim Ziyaei Halimehjani,Bernhard Breit
摘要
Rhodium-catalyzed intramolecular cyclization of nitrogen-tethered allenols was investigated for the synthesis of functionalized morpholines. By using this strategy, various N-protected 2,5- and 2,6-disubstituted as well as 2,3,5- and 2,5,6-trisubstituted morpholines were obtained via an atom-economic pathway with high to excellent yields, diastereo- and enantioselectivities (up to 99% yield, up to >99 : 1 dr and up to >99.9 ee). The utilities of the synthesized morpholines in ozonolysis, hydration, metathesis and epoxidation reactions were also investigated.
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