The 2023 Precision Oncology Summit was held in San Francisco, CA on October 7 th and 8 th , focusing on actionable strategies addressing personalized treatment to improve patient outcomes. This manuscript summarizes the discussion and key learning points from the precision medicine clinical science symposium in the implementation of Precision Oncology into the diagnostic and therapeutic armamentarium. This topic encompasses the advancement of molecular imaging in precision medicine and machine learning (ML) as a strategy to enhance precision oncology by individualizing patient treatments.