金黄色葡萄球菌
生物膜
细胞外
微生物学
殖民地化
马拉色菌
生物
细菌
细胞生物学
遗传学
作者
Xin Liu,Xiaoyu Guo,Xiaomin Su,Bin Ji,Yawei Chang,Qichao Huang,Zhongwei Yuan,Hairong Zheng,Pan Wang
出处
期刊:ACS Infectious Diseases
[American Chemical Society]
日期:2024-01-31
卷期号:10 (2): 624-637
标识
DOI:10.1021/acsinfecdis.3c00511
摘要
The colonizing microbiota on the body surface play a crucial role in barrier function. Staphylococcus aureus (S. aureus) is a significant contributor to skin infection, and the utilization of colonization resistance of skin commensal microorganisms to counteract the invasion of pathogens is a viable approach. However, most studies on colonization resistance have focused on skin bacteria, with limited research on the resistance of skin fungal communities to pathogenic bacteria. Extracellular vehicles (EVs) play an important role in the colonization of microbial niches and the interaction between distinct strains. This paper explores the impact of Malassezia restricta (M. restricta), the fungus that dominates the normal healthy skin microbiota, on the proliferation of S. aureus by examining the distribution disparities between the two microorganisms. Based on the extraction of EVs, the bacterial growth curve, and biofilm formation, it was determined that the EVs of M. restricta effectively suppressed the growth and biofilm formation of S. aureus. The presence of diverse metabolites was identified as the primary factor responsible for the growth inhibition of S. aureus, specifically in relation to glycerol phospholipid metabolism, ABC transport, and arginine synthesis. These findings offer valuable experimental evidence for understanding microbial symbiosis and interactions within healthy skin.
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