小头畸形
脑病
医学
身材矮小
阶段(地层学)
儿科
序列(生物学)
缺氧缺血性脑病
物理医学与康复
神经科学
内科学
心理学
生物
遗传学
古生物学
作者
Mohammad Golshan Tafti,Mohammadali Jafari,Seyed Reza Mirjalili,Razieh Fallah,Farimah Shamsi
标识
DOI:10.18502/ijrm.v22i1.15235
摘要
Background: Hypoxic-ischemic encephalopathy (HIE), caused due to reduced oxygenation and brain blood flow, occurs in 1-8 per 1000 live full-term births in developed countries and up to 26 per 1000 live in the developing world. The growth status of survivors of birth HIE has not been evaluated sufficiently.
Objective: This study evaluated, the growth parameters (weight, height, and head circumference) of neonates with Sarnat stage 2 of HIE at 6, 10, and 12 months and its relationship with findings of neonatal brain diffusion-weighted imaging (DWI) sequence.
Materials and Methods: Medical records and growth parameters of 35 neonates with gestational age > 34 wk who were admitted with stage 2 of HIE in Neonatal Intensive Care Unit of Shahid Sadoughi hospital, Yazd, Iran from March 2021-March 2022, and its relationship with neonatal brain DWI sequence finding was evaluated.
Results: 15 girls and 20 boys with a mean birth weight of 2880.3 ± 221.8 gr were evaluated. Conventional magnetic resonance imaging and DWI were found to be abnormal in 6 (17.1%) and 18 neonates (51.4%). The most abnormal finding of DWI was high signal in basal ganglia/thalamus in 9 neonates (25.7%). Abnormal DWI is more frequent in neonates with seizures and low birth weight. Hospital stay days were more prolonged in neonates with abnormal DWI. Microcephaly at 12 months was more frequent in children with abnormal DWI.
Conclusion: In survivors of moderate neonatal HIE, abnormal brain DWI sequence might predict inappropriate head growth, and need close medical and nutritional interventions for growth improvement.
Key words: Hypoxic ischemia encephalopathy, Magnetic resonance imaging, Diffusion weighted imaging, Microcephaly, Underweight.
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