Smart Enzyme‐Like Polyphenol‐Copper Spray for Enhanced Bacteria‐Infected Diabetic Wound Healing

Abstract Developing functional medical materials is urgent to treat diabetic wounds with a high risk of bacterial infections, high glucose levels and oxidative stress. Here, a smart copper‐based nanocomposite acidic spray has been specifically designed to address this challenge. This copper‐based nanocomposite is pH‐responsive and has multienzyme‐like properties. It enables the spray to effectively eliminate bacteria and alleviate tissue oxidative pressure, thereby accelerating the healing of infected diabetic wounds. The spray works by generating hydroxyl radicals through catalysing H 2 O 2 , which has a high sterilization efficiency of 97.1%. As alkaline micro‐vessel leakage neutralizes the acidic spray, this copper‐based nanocomposite modifies its enzyme‐like activity to eliminate radicals. This reduces the level of reactive oxygen species in diabetic wounds by 45.3%, leading to a similar wound‐healing effect between M1 diabetic mice and non‐diabetic ones by day 8. This smart nanocomposite spray provides a responsive and regulated microenvironment for treating infected diabetic wounds. It also offers a convenient and novel approach to address the challenges associated with diabetic wound healing.