DNA甲基化
甲基化
衰老
生物
表观遗传学
DNA
遗传学
内分泌学
医学
内科学
细胞生物学
生物信息学
生理学
基因
基因表达
作者
Jiahui Si,Yu Ma,Canqing Yu,Dianjianyi Sun,Yuanjie Pang,Pei Pei,Ling Yang,Iona Y. Millwood,Robin Walters,Yiping Chen,Huaidong Du,Xiaoyan Zheng,Daniel Avery,Junshi Chen,Zhengming Chen,Liming Liang,Liming Li,Jun Lv,Rory Collins,Richard Peto
标识
DOI：10.1161/circresaha.124.325066
摘要
Alterations in lipid metabolism and DNA methylation are 2 hallmarks of aging. Connecting metabolomic, epigenomic, and aging outcomes help unravel the complex mechanisms underlying aging. We aimed to assess whether DNA methylation clocks mediate the association of circulating metabolites with incident atherosclerotic cardiovascular disease (ASCVD) and frailty.
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