DNA甲基化
液体活检
肺癌
痰
表观遗传学
癌变
甲基化
支气管肺泡灌洗
胎儿游离DNA
活检
癌症
医学
癌症研究
生物标志物
阶段(地层学)
病理
肿瘤科
DNA
生物
肺
内科学
基因
基因表达
遗传学
肺结核
胎儿
古生物学
产前诊断
怀孕
作者
Peilong Li,Shibiao Liu,Du Li,Ghazal Mohseni,Yi Zhang,Chuanxin Wang
标识
DOI:10.1186/s13148-022-01337-0
摘要
Abstract Lung cancer (LC) is the main cause of cancer-related mortality. Most LC patients are diagnosed in an advanced stage when the symptoms are obvious, and the prognosis is quite poor. Although low-dose computed tomography (LDCT) is a routine clinical examination for early detection of LC, the false-positive rate is over 90%. As one of the intensely studied epigenetic modifications, DNA methylation plays a key role in various diseases, including cancer and other diseases. Hypermethylation in tumor suppressor genes or hypomethylation in oncogenes is an important event in tumorigenesis. Remarkably, DNA methylation usually occurs in the very early stage of malignant tumors. Thus, DNA methylation analysis may provide some useful information about the early detection of LC. In recent years, liquid biopsy has developed rapidly. Liquid biopsy can detect and monitor both primary and metastatic malignant tumors and can reflect tumor heterogeneity. Moreover, it is a minimally invasive procedure, and it causes less pain for patients. This review summarized various liquid biopsies based on DNA methylation for LC. At first, we briefly discussed some emerging technologies for DNA methylation analysis. Subsequently, we outlined cell-free DNA (cfDNA), sputum, bronchoalveolar lavage fluid, bronchial aspirates, and bronchial washings DNA methylation-based liquid biopsy for the early detection of LC. Finally, the prognostic value of DNA methylation in cfDNA and sputum and the diagnostic value of other DNA methylation-based liquid biopsies for LC were also analyzed.
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