Prevalence and Risk Factors of Stroke in Patients with Nonvalvular Atrial Fibrillation: A Case-Control Study

To analyze the prevalence and influencing factors of stroke in patients with non-valvular atrial fibrillation (SIPWNVAF), and to provide a reference basis for the prevention and control of stroke. Data were obtained from the China National Stroke Screening Survey (CNSSS). From January 2016 to December 2023, a total of 15471 permanent residents aged ≥ 40 years in Yinchuan were screened. Patients with non-valvular atrial fibrillation (PWNVAF)who had their first stroke were selected as the stroke group(86 patients), and PWNVAF who had never had a stroke as the control group (477 patients). In 563 residents, the crude prevalence of SIPWNVAF was 15.28%, and the standardized prevalence was 9.33%. The multivariable logistic regression analysis revealed that age (OR 1.42, 95%Cl 1.17-1.71), Smoking (OR 2.10, 95%Cl 1.46-3.01), Drinking (OR 2.00, 95%Cl 1.28-3.13), Lack of exercise (OR 2.18, 95%Cl 1.18-4.03), Family history of stroke (OR 4.39, 95%Cl 1.82-10.57), Hypertension (OR 1.94, 95%Cl 1.03-3.63), Diabetes (OR 3.10, 95%Cl 1.37-7.05), Dyslipidemia (OR 2.15, 95%Cl 1.16-3.99), HCY ≥ 15 umol/l (OR 2.13, 95%Cl 1.14-3.97), Carotid atherosclerosis (CAS) (OR 2.86, 95%Cl 1.53-5.37) was an independent risk factor, but educational level (OR 0.31, 95%Cl 0.17-0.58) was a protective factor for SIPWNVAF. The stroke group is significantly more burdened by other independent common risk factors for stroke.