细胞内
一氧化氮
化学
光敏剂
细胞凋亡
一氧化碳
光动力疗法
生物物理学
胶束
细胞生物学
生物化学
光化学
催化作用
生物
有机化学
物理化学
水溶液
作者
Zhiqiang Shen,Wei Jiang,Shaoqiu Zheng,Siyuan Luo,Zixuan Guo,Qin Wang,Yucai Wang,Jinming Hu
出处
期刊:Angewandte Chemie
[Wiley]
日期:2025-01-09
卷期号:64 (7): e202419939-e202419939
被引量:27
标识
DOI:10.1002/anie.202419939
摘要
Understanding the interplay between gasotransmitters is essential for unlocking their therapeutic potential. However, achieving spatiotemporally controlled co-delivery to target cells remains a significant challenge. Herein, we propose an innovative strategy for the intracellular co-delivery of carbon monoxide (CO) and nitric oxide (NO) gasotransmitters under clinically relevant wavelengths. This approach rationally couples aerobic photooxidative and anaerobic photocatalytic reactions within a polymeric micelle platform, using palladium(II) tetraphenyltetrabenzoporphyrin (PdTPTBP) as both photosensitizer and photocatalyst. Notably, the photooxidation-mediated release of CO generates a local hypoxic microenvironment, which facilitates the photoredox catalyzed release of NO. This self-adaptive micelle platform enables efficient uptake by tumor cells and intracellular co-delivery of CO and NO under 630 nm light irradiation, demonstrating potent anti-tumor activity in a 4T1 tumor-bearing mouse model via the synergistic induction of mitochondrial apoptosis.
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