One-step synthesis of cyanated pyrazolo[1,5-a]pyridines utilizing N-aminopyridines as a 1,3-dipole and a nitrogen source

By utilizing the dual reactivity function of N -aminopyridinium ylides, we developed a direct [3 + 2]-cycloaddition of N -aminopyridinium ylides and ynals to build the pyrazolo[1,5- a ]pyridine core while introducing a cyano group.