头孢菌素
生物膜
铜绿假单胞菌
抗生素
抗菌剂
微生物学
金黄色葡萄球菌
头孢菌素C
化学
头孢菌素类抗生素
抗生素耐药性
细菌
组合化学
生物
遗传学
作者
Inga S. Shchelik,Karl Gademann
出处
期刊:ACS Infectious Diseases
[American Chemical Society]
日期:2022-10-17
卷期号:8 (11): 2327-2338
被引量:3
标识
DOI:10.1021/acsinfecdis.2c00393
摘要
Due to a steady increase in microbial resistance, there is a need to increase the effectiveness of antibiotic performance by involving additional mechanisms of their penetration or retention for their better action. Cephalosporins are a successful group of antibiotics to combat pathogenic microorganisms, including drug-resistant strains. In this study, we investigated the effect of newly synthesized cephalosporin derivatives with cyclic disulfide modifications against several Gram-positive and Gram-negative strains as well as against biofilm formation. The incorporation of asparagusic acid was found to be effective in improving the activity of the drug against Gram-negative strains compared to the all carbon-control compounds. Furthermore, we could demonstrate the successful reduction of biofilm formation for Staphylococcus aureus and Pseudomonas aeruginosa at similar concentrations as obtained against planktonic cells. We propose that the incorporation of cyclic disulfides is one additional strategy to improve antibiotic activity and to combat bacterial infections.
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