Facile One-Pot Approach to the Synthesis of Alkyl Piperazine-1-carbodithioates as Hemolytic and Thrombolytic Agents

A polyethylene glycol (PEG)-promoted methodology has been utilized for synthesis of piperazine-based dithiocarbamates. One-pot reaction of N-methylpiperazine and N-Boc-piperazine with various substituted arylmethyl bromides or 2-bromo-1-phenylethanone and carbon disulfide using PEG as solvent afforded the target S-alkyl piperazine-1-carbodithioates in high yields (80–90%). The synthesized compounds were charac­terized by 1H and 13C NMR and FT-IR spectroscopy. Furthermore, cytotoxic potential of these piperazine derivatives was evaluated via hemolysis and thrombolysis. The synthesized compounds displayed hemolytic potential in the range from 0.1±0.004 to 9.63±0.249% and thrombolytic activity in the range from 48.17±0.016 to 63.56±0.124%.