超分子化学
聚乙二醇
环糊精
分子
化学计量学
PEG比率
化学
药物输送
分子间力
六角相
化学工程
粉末衍射
六方晶系
结晶学
纳米技术
材料科学
有机化学
经济
工程类
财务
作者
Soumya Kundu,Kenjirou Higashi,Makoto Takamizawa,Keisuke Ueda,Kunikazu Moribe
标识
DOI:10.1021/acs.cgd.3c00619
摘要
The drug/(PEG/γ-CD-PPRX) complex is a unique multicomponent supramolecular structure where the drug molecules are incorporated in the intermolecular spaces of the polypseudorotaxane (PPRX) prepared from polyethylene glycol (PEG) and γ-cyclodextrin (γ-CD). Herein, we report a sealed-heating preparation method to obtain an unanticipated polymorphic form of the drug/(PEG/γ-CD-PPRX) complex, which is the hexagonal-columnar (HC) form. The encapsulation efficiency of the six guest drugs was evaluated. The crystalline structural changes and the guest encapsulation monitored by powder X-ray diffraction revealed that a low sealed-heating temperature with a small amount of water was the optimal preparation condition for obtaining the HC form complex. The solution-state 1H nuclear magnetic resonance measurement demonstrated that stoichiometric complexation was dependent on the cross-sectional area of the guest drug molecule. However, stoichiometric complexation could not be achieved with all guest drugs, and the encapsulation efficiency was found to be governed by the guest drug properties, such as vapor pressure and molecular size. The findings of this study would contribute to understanding the complexation behavior of guest molecules in multicomponent supramolecular complexes and offer new insights into the fabrication of novel ordered supramolecular structures.
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