减肥
干预(咨询)
呼吸商
医学
期限(时间)
生物
内科学
生理学
内分泌学
肥胖
量子力学
精神科
物理
作者
Xiao Li,Dalia Perelman,Ariel K. Leong,Gabriela Fragiadakis,Christopher D. Gardner,Michael P Snyder
标识
DOI:10.1016/j.xcrm.2022.100870
摘要
Summary
To understand what determines the success of short- and long-term weight loss, we conduct a secondary analysis of dietary, metabolic, and molecular data collected from 609 participants before, during, and after a 1-year weight-loss intervention with either a healthy low-carbohydrate (HLC) or a healthy low-fat (HLF) diet. Through systematic analysis of multidomain datasets, we find that dietary adherence and diet quality, not just caloric restriction, are important for short-term weight loss in both diets. Interestingly, we observe minimal dietary differences between those who succeeded in long-term weight loss and those who did not. Instead, proteomic and gut microbiota signatures significantly differ between these two groups at baseline. Moreover, the baseline respiratory quotient may suggest a specific diet for better weight-loss outcomes. Overall, the identification of these dietary, molecular, and metabolic factors, common or unique to the HLC and HLF diets, provides a roadmap for developing individualized weight-loss strategies.
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