转录因子
免疫疗法
生物
免疫系统
肿瘤微环境
癌症免疫疗法
先天免疫系统
癌症研究
纤维肉瘤
免疫
癌症
免疫学
遗传学
基因
作者
Yunke Wang,Fuming Qiu,Jun Yan
标识
DOI:10.1016/j.trecan.2022.12.002
摘要
In innate immune cells, the transcription factor cellular musculoaponeurotic fibrosarcoma (c-Maf) influences cell fate and function through molecular and metabolic programming, thereby influencing immune homeostasis and antitumor immunity. We discuss recent c-Maf landmark discoveries with a focus on the immunosuppressive tumor microenvironment (TME) and provide a new perspective on c-Maf-targeted cancer immunotherapy.
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