自愈水凝胶
明胶
材料科学
控制释放
复合数
傅里叶变换红外光谱
化学工程
药物输送
高分子化学
纳米技术
复合材料
有机化学
化学
工程类
作者
Zuokun Zhang,Sisi Zhou,Xingui Wang,Ruixing Liang,Xingxin Sheng,Yanjun Zhu,Lei Huang,Binbin Zhou,Ming Zhong
标识
DOI:10.1016/j.mtcomm.2023.106425
摘要
Conventional self-assembled peptide hydrogels have poor mechanical properties and tend to release abruptly when they are used as drug carriers, limiting the application of these materials in biomedical field. In this work, gelatin was embedded in a pH-responsive peptide Ac-FALNLAKD-NH2 (PEP) to construct gelatin/peptide composite hydrogels (Gel/PEP) for controlling the delivery of the anticancer drug chelerythrine (CHE). The physicochemical properties of Gel/PEP composite hydrogels were evaluated. The results of circular dichroism and Fourier transform infrared spectroscopy characterization showed that compared with PEP hydrogels and gelatin, the Gel/PEP composite hydrogel has a superposition of two secondary structures, in which β-sheet and random coil accounted for 44.7 % and 55.3 % of the conformation, respectively. Rheology and scanning electron microscope characterization confirmed that the Gel/PEP hydrogel has a highly dense nanofibrous meshwork structure, which enhances mechanical and injectable properties. In addition, the encapsulation rate of CHE could reach more than 97 % at a gelatin/peptide mass ratio of 7:1. More importantly, in vitro results showed that the composite hydrogel still had good pH and thermal response performance, which can achieve controlled release of CHE. Therefore, it is possible to synthesize supramolecular drug release soft materials by composite of gelatin and peptide hydrogels.
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