Gold-Catalyzed Regio- and Stereoselective Alkenylation of Quinoline N-Oxides with Allenamides

A gold-catalyzed cycloaddition/ring opening of allenamides with quinoline N-oxides has been developed, which provides C2-alkenylated quinolines with high E selectivity in moderate to high yields. It is noted that quinoline N-oxides with a C8 or C7 substituent are crucial for this catalytic reaction.