硫索恶唑
胆红素
口服
医学
给药途径
药理学
内科学
化学
生物化学
抗生素
四环素
作者
Robert L. Suber,John C. Gudat,G. T. Edds
标识
DOI:10.1002/jps.2600710118
摘要
Administration of sulfonamides during periods of hepatobiliary failure or hepatic immaturity increases the toxic potential of unconjugated or indirect bilirubin. A small but statistically significant increase of indirect, or unconjugated bilirubin was noted in dogs after oral administration of sulfisoxazole (100 mg/kg). A similar increase was not observed in swine after oral or intravenous administration of sulfisoxazole (100 mg/kg) or in humans (∼28 mg/kg) after oral administration or in dogs (100 mg/kg) after intravenous administration. Total and conjugated bilirubin showed small but statistically significant increases and were significantly correlated in dogs after oral and intravenous administration of sulfisoxazole (100 mg/kg) and in swine after oral administration of sulfisoxazole (100 mg/kg). There was a significant negative correlation between conjugated and indirect bilirubin, while total bilirubin increased in dogs after oral and intravenous administration of sulfisoxazole. These data illustrate a difference in species and administration route when attempting to assess the potential toxicity of bilirubin.
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