医学
细胞培养
移行细胞癌
病理
尿路上皮细胞
癌
非整倍体
细胞
过渡细胞
腺癌
黑色素瘤
膀胱癌
癌症
癌症研究
内科学
生物
染色体
遗传学
基因
作者
H. Barton Grossman,Gary Wedemeyer,Lele Ren,Golder N. Wilson,Beth A. Cox
标识
DOI:10.1016/s0022-5347(17)45139-1
摘要
From January, 1981 through June, 1982 specimens from 21 patients with bladder (urothelial) cancer were placed in tissue culture, and one long term cell line was established (5%). From July, 1982 through February, 1984, using an improved culture medium, seven long term cell cultures were established from 21 patients (33%). In addition, one long term culture from a patient with a bladder melanoma was established using the standard culture medium. The nine cell cultures were derived from the following types of tumors: transitional cell carcinoma (6), adenocarcinoma (1), squamous cell carcinoma (1) and melanoma (1). All of the cell lines have produced tumors in athymic nude mice except for one transitional cell carcinoma. All of the cultures demonstrate aneuploidy. Homogeneously staining regions have been seen in some cell cultures. A common marker chromosome has not been identified.
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