基因组
生物
微生物群
胆汁酸
寄主(生物学)
人类微生物组计划
肠道菌群
人体微生物群
计算生物学
生理学
基因
生物信息学
遗传学
免疫学
生物化学
作者
Baolei Jia,Dongbin Park,Yoonsoo Hahn,Che Ok Jeon
出处
期刊:Gut microbes
[Informa]
日期:2020-04-24
卷期号:11 (5): 1300-1313
被引量:58
标识
DOI:10.1080/19490976.2020.1748261
摘要
Bile acid metabolism by the gut microbiome exerts both beneficial and harmful effects on host health. Microbial bile salt hydrolases (BSHs), which initiate bile acid metabolism, exhibit both positive and negative effects on host physiology. In this study, 5,790 BSH homologs were collected and classified into seven clusters based on a sequence similarity network. Next, the abundance and distribution of BSH in 380 metagenomes from healthy participants were analyzed. It was observed that different clusters occupied diverse ecological niches in the human microbiome and that the clusters with signal peptides were relatively abundant in the gut. Then, the association between BSH clusters and 12 human diseases was analyzed by comparing the abundances of BSH genes in patients (n = 1,605) and healthy controls (n = 1,540). The analysis identified a significant association between BSH gene abundance and 10 human diseases, including gastrointestinal diseases, obesity, type 2 diabetes, liver diseases, cardiovascular diseases, and neurological diseases. The associations were further validated by separate cohorts with inflammatory bowel diseases and colorectal cancer. These large-scale studies of enzyme sequences combined with metagenomic data provide a reproducible assessment of the association between gut BSHs and human diseases. This information can contribute to future diagnostic and therapeutic applications of BSH-active bacteria for improving human health.
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