MicroRNA miR-1249 downregulates adenomatous polyposis coli 2 expression and promotes glioma cells proliferation.

. Furthermore, bioinformatic and experimental approaches showed that miR-1249 targets and suppresses APC2 expression, an important Wnt/β-Catenin pathway-regulated factor. These data suggested that miR-1249 could be a novel therapeutic target of microRNA-mediated cell proliferation in glioma.