脂肪组织
2019年冠状病毒病(COVID-19)
祖细胞
血管紧张素转化酶2
肥胖
冠状病毒
爆发
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
生物
癌症研究
疾病
内科学
内分泌学
医学
病毒学
干细胞
细胞生物学
传染病(医学专业)
作者
Xiaoyun Jia,Chenghong Yin,Shan Lu,Y Chen,Liu Q,Jing Bai,Yao Lu
标识
DOI:10.20944/preprints202002.0315.v1
摘要
The spread of 2019 novel coronavirus disease (COVID-19) throughout the world has been a severe challenge for public health. The human angiotensin-converting enzyme 2 (ACE2) has a remarkably high affinity binding to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). By the search for network database and re-analysis of pubic data, we found the level of ACE2 expression in adipose tissue was higher than that in lung tissue, which indicated the adipose tissue might be vulnerable to SARS-CoV-2 as well; the levels of ACE2 expressed by adipocytes and adipose progenitor cells were similar between non-obese individuals and obese individuals, but obese individuals have more adiposes so as to increase the number of ACE2-expressing cells; the expression of ACE2 in tumor tissues posed by five different types of cancers increased significantly compared with that in adjacent tissues. Thus, we suggest that more attentions might be given to obese individuals and the five types of cancer patients during the outbreak of COVID-19.
科研通智能强力驱动
Strongly Powered by AbleSci AI