干细胞
生物
干细胞衰老理论
表观遗传学
细胞生物学
极性(国际关系)
造血
成体干细胞
造血干细胞
体细胞
细胞分化
遗传学
细胞
干细胞因子
基因
作者
Eva Mejia-Ramirez,Hartmut Geiger,Maria Carolina Florian
摘要
Abstract Changes of polarity in somatic stem cells upon aging or disease lead to a functional deterioration of stem cells and consequently loss of tissue homeostasis, likely due to changes in the mode (symmetry versus asymmetry) of stem cell divisions. Changes in polarity of epigenetic markers (or ‘epi-polarity’) in stem cells, which are linked to alterations in chromatin architecture, might explain how a decline in the frequency of epipolar stem cells can have a long-lasting impact on the function of especially aging stem cells. The drift in epipolarity might represent a novel therapeutic target to improve stem cell function upon aging or disease. Here we review basic biological principles of epigenetic polarity, with a special focus on epipolarity and aging of hematopoietic stem cells.
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