多裂肌
医学
腰痛
腰椎
可视模拟标度
肌肉萎缩
萎缩
炎症
内科学
病理
外科
替代医学
作者
Xiaolong Chen,Paul W. Hodges,Gregory James,Ashish D. Diwan
出处
期刊:Spine
[Ovid Technologies (Wolters Kluwer)]
日期:2020-12-07
卷期号:46 (10): 678-686
被引量:10
标识
DOI:10.1097/brs.0000000000003863
摘要
Study Design. Observational study. Objective. The aim of this study was to evaluate whether inflammatory and/or muscle regeneration markers in paraspinal tissues (multifidus muscle/fat) during microdiscectomy surgery in patients with lumbar disc herniation (LDH) with radiculopathy, differ between individuals with good or poor outcome. Summary of Background Data. Structural back muscle changes, including fat infiltration, muscle atrophy, and fiber changes, are ubiquitous with LBP and are thought to be regulated by inflammatory and regeneration processes. Muscle changes might be relevant for recovery after microdiscectomy, but a link between expression of inflammatory and muscle regeneration genes in paraspinal tissues and clinical outcome has not been tested. Method. Paraspinal tissues from deep multifidus muscles and fat (intramuscular, sub-cutaneous, epidural) were harvested from twenty-one patients with LDH undergoing microdiscectomy surgery. Quantitative polymerase chain reaction (qPCR) measured expression of 10 genes. Outcome was defined as good (visual analogue scale (VAS) low back pain (LBP)+) or poor (VAS LBP−) by an improvement of >33% or ≤33% on the pain VAS, respectively. Good functional improvement was defined as 25% improvement on the physical functioning scale (PFS). Results. Brain-derived neurotrophic factor expression in deep multifidus was 91% lower ( P = 0.014) in the VAS LBP- than VAS LBP+ group. Expression of interleukin-1β in subcutaneous fat was 48% higher ( P = 0.026) in the VAS LBP– than VAS LBP+ group. No markers differed based on PFS. Conclusion. Results show a relationship between impaired muscle regeneration profile in multifidus muscle and poor outcome following microdiscectomy for LDH. Inflammatory dysregulation in subcutaneous fat overlying the back region might predict poor surgical outcome. Level of Evidence: 4
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