毒蕈碱乙酰胆碱受体
神经科学
变构调节
精神分裂症(面向对象编程)
乙酰胆碱
心理学
变构调节剂
药物发现
毒蕈碱乙酰胆碱受体M4
受体
医学
药理学
生物信息学
精神科
生物
内科学
作者
Sean P. Moran,James Maksymetz,P. Jeffrey Conn
标识
DOI:10.1016/j.tips.2019.10.007
摘要
Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex behaviors such as cognition, movement, and reward, making them ideally situated as potential drug targets for the treatment of several brain disorders. Recent advances in the discovery of subtype-selective allosteric modulators for mAChRs has provided an unprecedented opportunity for highly specific modulation of signaling by individual mAChR subtypes in the brain. Recently, mAChR allosteric modulators have entered clinical development for Alzheimer's disease (AD) and schizophrenia, and have potential utility for other brain disorders. However, mAChR allosteric modulators can display a diverse array of pharmacological properties, and a more nuanced understanding of the mAChR will be necessary to best translate preclinical findings into successful clinical treatments.
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