脱氢
化学
氧化磷酸化
立体选择性
功能群
催化作用
基质(水族馆)
分子氧
组合化学
原子经济
有机化学
生物化学
海洋学
地质学
聚合物
作者
Bao-Yin Zhao,Xinglong Zhang,Ruili Guo,Meng-Yue Wang,Ya‐Ru Gao,Yongqiang Wang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-02-02
卷期号:23 (4): 1216-1221
被引量:9
标识
DOI:10.1021/acs.orglett.0c04174
摘要
An efficient and unprecedented strategy for the synthesis of 1,4-enediones from saturated ketones has been developed via palladium-catalyzed oxidative dehydrogenation. The protocol employs molecular oxygen as the sole oxidant and represents an atom- and step-economic process. The approach showed broad substrate scope, good functional group tolerance, and complete E-stereoselectivity. The reaction mechanism has been investigated through deuterium-labeling experiments and intermediate experiments.
科研通智能强力驱动
Strongly Powered by AbleSci AI