Association between time in range, a novel measurement of glycemic control and islet secretory function in chinese patients with type 2 diabetes mellitus—An observational study

Abstract

Aims

To explore the association between dynamic islet secretory function and TIR (time in range), a new valuable metric of glycemic control in type 2 diabetes (T2D).

Methods

In this observational study 256 patients with type 2 diabetes were included and continuous glucose monitoring system (CGMS) were applied to monitor blood glucose and also the calculation of TIR [the time spent in an individual's target glucose range (usually 3.9–10 mmol/L)]. The participants were divided into 3 groups according to the tertiles of TIR, 85 cases with TIR ≥ 65.05% (T1 group), 86 cases with 41.84 < TIR ≤ 65.05% (T2 group) and 85 cases with TIR < 41.84% (T3 group). Serum glucagon (GLA_0h, GLA_0.5h, GLA_1h, GLA_2h, GLA_3h), C-peptide (Cp_0h, Cp_0.5h, Cp_1h, Cp_2h, Cp_3h) concentration at different time points were measured after a 100 g standard steamed buns meal test to assess the pancreatic alpha cell and beta cell function. Spearman correlation analysis and multivariate linear stepwise regression analysis were adopted for statistical analysis.

Results

The average age and diabetes duration of all the participants were separately 56.09 ± 13.8 years and 8.0 (4.0,15.0) years. Compared with patients in T1 group, participants in group T2 and T3 tend to have a lower concentration of C-peptide at all time points, as well as GLA_0h, GLA_2h and GLA_3h (p < 0.05). TIR was positively correlated with C-peptide at different time points, area under the curve of C-peptide in half an hour (AUC_Cp0.5h), GLA_0h, GLA_3h, area under the curve of glucagon in half an hour (AUC_GLA0.5h)(r_s = 0.263, 0.414, 0.510, 0.587, 0.528, 0.360, 0.259, 0.144 and 0.208, respectively, p < 0.05) and was negatively correlated with the increment of serum glucagon from baseline at 0.5 h, 1 h and 2 h after the standard energy loaded(△GLA_0.5h, △GLA_1h, △GLA_2h)(r_s = −0.152,-0.172 and −0.203, respectively, p < 0.05). Cp_2h, Cp_0h and GLA_0h were independent factors for TIR (β = 6.558,-6.930, 0.247, respectively, p < 0.01).

Conclusion

Both islet alpha cell and beta cell secretory function have important influence on TIR, a novel vital index of glycemic fluctuation.