三氟甲基
磺酰
化学
组合化学
表面改性
有机化学
物理化学
烷基
作者
Samir Bouayad‐Gervais,Thomas Scattolin,Franziska Schoenebeck
标识
DOI:10.1002/anie.202004321
摘要
Reported herein is the first efficient strategy to synthesize a broad range of unsymmetrical N-CF3 hydrazines, which served as platform to unlock numerous currently inaccessible derivatives, such as tri- and tetra-substituted N-CF3 hydrazines, hydrazones, sulfonyl hydrazines, and valuable N-CF3 indoles. These compounds proved to be remarkably robust, being compatible with acids, bases, and a wide range of synthetic manipulations. The feasibility of RN(CF3 )-NH2 to function as a directing group in C-H functionalization is also showcased.
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