Relationship between MAPK/ERK signaling pathway and tumor angiogenesis

MAPK/ERK signal pathway involves in the regulation of tumor growth and metastasis, and tumor growth cannot do without angiogenesis. Tumor angiogenesis requires the participation of vascular endothelial cells, including endothelial cell proliferation, migration and invasion. So as the core of this network signal: Ras/Raf/MEK/ERK path-way, this paper focus on the modulation between various MAPK/ERK signaling links and tumor angiogenesis, for mak-ing further study of the inferred in inhibiting tumor growth.