Objective:To investigate the analgestic activity of the water extract of fructus of Cucurbita pepo.Methods:The analgestic activity of the water extract of fructus of Cucurbita pepo.was investigated by the tail-flick and hot-plate procedure.Results:The the water extract of fructus of Cucurbita pepo.have no analgesic effect in 90min after being adminastrationed,but the analgesic effect was observed after being adminastrationed for 150min.Conclusion:The the water extract of fructus of Cucurbita pepo.have some analgesic effect.