Objective To report one successful surgery on a high clination sinus floor lift distally. Methods A 39 years-old male patient received sinus lift because of the first molar missing in the left upper jaw. CT scan based three-dimensional reconstruction analysis showed that the inclination of sinus floor was 60 degree and the distance between top of the alveolar bone and the sinus floor ranged from 14.4 mm to 9.2 mm. A simulating operation was done on the patient's rapid prototyping model and a surgical guide was fabricated. During the surgical guide aided operation a 2.2 mm twist drill was applied to drill the top of alveolar bone,stopping at a distance of 13 mm deep without penetrating the sinus floor. A Sinustech reamer was used to cut a hole in the sinus floor and the sinus membrane was lifted simultaneously. Finally the implant was introduced and its initial stability checked. Results No damage or laceration of the sinus membrane was observed. The sinus floor was lift distally. The half tip of the implant was tight imbedded to the alveolar bone and the other half root tip of the implant covered by intact membranes. Conclusion The angle and depth of twist drills and Sinustech reamers were controlled precisely by surgical guide. That is the key for the success of sinus lift in the patient who has a high inclination sinus floor.