Significance of TEL-AML1 Fusion Gene Expression in Children with Acute Lymphoblastic Leukemia

Objective To study the frequency and clinical significance of transloation,ets,leukemia-acute myeloblasticleukemia1 (TEL-AML1) fusion gene in children with acute lymphoblastic leukemia (ALL).Methods Base on MIC(morphology,immunology and cytogenetics),nested reverse transiption-polymerase chain reaction(RT-PCR) was performed to detect TEL-AML1 fusion gene.Results TEL-AML1 fusion gene was found in 22.2% (20/90) of patients with newly diagnosed ALL and 23.7% (19/80) in B lineage ALL cases.The fusion gene was found in 1 T lineage ALL case.Fifteenth days′ complete remission rate and early mortality were no difference between TEL-AML1 fusion gene positive group and negative group.Conclusion Therapeutic results are not different between TEL-AML1 fusion gene positive group and negative group lately.