Study on Selective α-Bromination Reaction of 4-acetyl-guaiacol

When bromine was used to bromization reaction with 4-acetyl-guaiacol,the product bromide incompletely or super bromide partial,and the selectivity was poor.α-bromide ketone can synthesized in the mixture of chloroform and ethyl acetate with CuBr2 and ketone,reaction shows good selectivity to α-position.So we can use CuBr2 instead of bromine reactions with 4-acetyl-guaiacol.The struture of products is analysized by FT-IR and 1H-NMR,and the effect to yield such as reaction time,temperature,the mixture ration of chloroform and ethyl acetate is studied.