Characteristic of Tol2 Transposon and Its Application in Gene Transfer

The medaka fish Tol2 element in hAT family is a only autonomous transposon that can encode a fully functional transposase at present.The Tol2 transposon system has been proved to be active in all vertebrate cells tested thus far,including zebrafish,Xenopus,chicken,mouse and human.The Tol2 transposon is being applied to transgenic studies in these vertebrates,and has broad application prospects in gene transfer in the future.Therefore,the structure of Tol2 transposable element,its transposition mechanism and the latest developments are reviewed in this paper,for the sake of providing some references for future study.