Toxicological study of Momordica Charantia L. and Folium Mori Mixture

Objective Toxicity tests of Momordica Charantia L. and Folium Mori Mixture were conducted. Methods The safety of Momordica Charantia L. and Folium Mori Mixture was evaluated systematically by a series of acute,mutagenic and sub-chronic toxicological tests. Results The acute toxicity test showed that the oral maximum tolerated dose of Momordica Charantia L. and Folium Mori Mixture was more than 20. 0 g / kg body weight in mice. No mutagenicity was found,as judged by mouse bone marrow cell micronucleus test and mouse sperm abnormality test. In the subchronic study,no deaths or clinical signs,or abnormal hematological,clinical,chemical and histopathological changes had been found in rats after being treated using 25,50,100 times as recommended dosage for adult for 30 days. Conclusions The results indicated that no significant toxicological effect was found using Momordica Charantia L. and Folium Mori Mixture.