Three kinds of liquid cooling systems for computer CPU(commonly used liquid cooling loop system,heat pipe cooling system and liquid injection cooling system) and their coolants(water,liquid metal and nano-fluids) are reviewed.Meanwhile,the advantages and disadvantages of the cooling systems and coolants are compared,poin-ting out that heat pipe cooling system and nano-fluids have greater competitive advantage.At last,some ideas on the development prospects of liquid cooling system and coolant are presented.